Effect of cruciferous vegetable consumption on heterocyclic aromatic amine metabolism in man

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Effect of cruciferous vegetable consumption on heterocyclic aromatic amine metabolism in man.

The consumption of cooked meat appears to predispose individuals to colonic cancer and heterocyclic aromatic amines (HA), formed during the cooking of meat, have been suggested as aetiological agents. Consumption of cruciferous vegetables is thought to protect against cancer. To study the effect of cruciferous vegetables on heterocyclic aromatic amine metabolism in man, a three-period, dietary ...

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GST polymorphism and excretion of heterocyclic aromatic amine and isothiocyanate metabolites after Brassica consumption.

Brassica vegetable intake has been associated with decreased risk and well-done meat intake has been associated with increased risk of cancers at multiple organ sites in epidemiologic studies. Experimental studies suggest a role of modulation of phase I and phase II metabolizing enzymes as one mechanism for these associations. Heterocyclic aromatic amines (HAAs) are carcinogens formed in meat t...

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Cruciferous vegetable consumption and lung cancer risk: a systematic review.

BACKGROUND Cruciferous vegetables, rich in isothiocyanates, may protect against lung cancer. Glutathione S-transferases are important in metabolizing isothiocyanates; hence, variants in GST genes may modify the association between cruciferous vegetable intake and lung cancer. We carried out a systematic review to characterize the association between cruciferous vegetable intake and lung cancer ...

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Heterocyclic aromatic amine [HCA] intake and prostate cancer risk: effect modification by genetic variants.

The association between heterocyclic aromatic amine (HCA) intake and prostate cancer (PCa) risk may be modified by genetic variation in enzymes involved in HCA metabolism. We examined this question in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition Heidelberg cohort. The study included 204 PCa cases and 360 matched controls. At baseline, parti...

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the washback effect of discretepoint vs. integrative tests on the retention of content in knowledge tests

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ژورنال

عنوان ژورنال: Carcinogenesis

سال: 2001

ISSN: 1460-2180

DOI: 10.1093/carcin/22.9.1413